Suicide Prevention Push in Argentina: Mental health groups and bereaved families are calling for urgent action after Argentina’s suicide rates among ages 15–34 rose sharply, with protests in Buenos Aires urging that “talking is prevention.” Drug Access for HIV Prevention: Gilead and PAHO announced a regional pathway to speed access to twice-yearly lenacapavir for HIV PrEP across Latin America and the Caribbean, aiming to close gaps in uptake. Rare Disease Treatment Update: The FDA approved Ultragenyx’s Fayuvi as the first treatment for Sanfilippo syndrome type A in children ages 2–5, highlighting a major step for pediatric neurodegenerative care. Biosimilar Partnerships: mAbxience and Sandoz signed a collaboration to develop an emicizumab biosimilar for hemophilia A, with mAbxience handling development and manufacturing and Sandoz leading global commercialization (excluding Argentina, Uruguay, Paraguay). Uruguay Health & Policy Context: Uruguay lawmakers advanced a Carlos Gardel birthday tribute bill, reviving a debate tied to official documentation and cultural belonging. Climate and Health Risk Watch: El Niño contingency planning is accelerating across Latin America, with Uruguay and parts of southern South America flagged for higher flood risk.